GenoRisk™ - ADxHealth™

Determine Your Genetic Risk for Late-Onset Alzheimer’s Disease

Determine your GenoRisk™.

GenoRisk Test *

The GenoRisk test provides a genetic risk score based on the evaluation of multiple genes to establish your genetic risk for late-onset Alzheimer’s disease. Your individualized report will provide your personal GenoRisk score.

*Not available to New York residents.

Get notified when this product is available!

What’s Measured

The GenoRisk panel evaluates 31 genetic variants found in 24 different genes. The test includes an evaluation of your ApoE status, a gene that alone accounts for approximately one-quarter of the heritability of Alzheimer’s disease. The GenoRisk score is based on a proprietary algorithm developed by a team of scientists and statisticians. All testing is performed in our CAP-accredited and CLIA-certified laboratory in Bellingham, WA.

DOWNLOAD GENORISK WHITE PAPER

WHAT’S INCLUDED

Your Kit Includes

Collection instruction manual

Saliva collection tube

Small funnel

Biohazard bag

Return shipping materials

WHAT’S INCLUDED

Your Kit Includes

Collection instruction manual

Saliva collection tube

Small funnel

Biohazard bag

Return shipping materials

How it Works

COLLECTING YOUR SAMPLE

PROCESSING YOUR SAMPLE

Collect and ship your sample to our lab.

RECEIVING YOUR RESULTS

Receive results in the palm of your hand.

The Science Behind GenoRisk

DNA is extracted from your saliva sample and processed on the Agena Bioscience® mass spectrometry testing platform.

DNA, or deoxyribonucleic acid, is the molecule within your cells that gives instructions to build the proteins needed for all of your body’s functions. DNA is bundled into a total of 23 chromosome pairs. Housed within these 46 individual chromosomes are an estimated 20,000 to 25,000 genes.

The Science Behind GenoRisk

You share 99.9% of your genetic code with other human beings. The 0.1% that is unique to you involves changes to specific nucleotide bases resulting in changes to specific genes, and in some cases, changes in risk for certain diseases. These different nucleotide arrangements are known as single nucleotide polymorphisms (“SNPs”).

Your unique genetic makeup is known as your “genotype.” The GenoRisk test evaluates 31 risk and protective SNPs, including apolipoprotein e (ApoE), associated with Alzheimer’s disease to provide you with an overall “GenoRisk” score.

The Science Behind GenoRisk

The GenoRisk score was developed by comparing data from 4 different independent studies of Alzheimer’s disease risk using different statistical prediction models. These models were then compared to determine the model that best predicted Alzheimer’s disease risk. The GenoRisk score was then adjusted for age and gender at birth, further personalizing the risk prediction.

This risk is then paired with evidence-based interventions to help you reduce the risk of Alzheimer’s disease, including information about diet, exercise, sleep, brain stimulation, stress reduction, and social interaction.

How This Benefits You

Knowledge is the first step in reducing your risk for Alzheimer’s disease.

Gain the motivation you need to make lifestyle changes to reduce your risk.

Understand how your risk could affect other members of your family.

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GenoRisk FAQs

Can ADx Health provide me with a referral to a genetic counselor?

ADx Health can provide you with a list of genetic counselors in your area.

Do you keep DNA from my sample? For how long?

No. We discard your sample 2 weeks after we finish running the tests you’ve asked us to run. We only keep it those 2 weeks in case we need to rerun a sample if there was some kind of problem processing it the first time.

How accurate is the test?

The technology used to identify individual SNPs has a high degree of accuracy. The resulting GenoRisk score is based on research of statistical models as discussed in the published research.

How often should I take the test?

This test is designed to be taken once, as your genetics do not change throughout your lifetime.

Shoud I share the results from GenoRisk testing with my primary physician or a specialist?

You are welcome to share the results of your GenoRisk test with your primary care physician or another healthcare provider as they will be able to discuss with you how they impact other areas of your health and lifestyle.

What are the risk factors for Alzheimer’s disease?

There are non-modifiable as well as modifiable risk factors for Alzheimer’s disease. Non-modifiable risk factors include age, gender at birth, and genetics. Modifiable risk factors include lifestyle behaviors such as diet and exercise as well as some medical conditions.

What happens if there’s new information or evidence around one of the genes you report?

To ensure that all of our tests stay up-to-date, ADx Health continually evaluates new evidence-based research to determine what modifications should be made to the information or results we provide. By simply reprinting your report, it will automatically update with the most current data and evidence available.

What if you add new gene(s) to the test?

You will be notified of the change to the test and we will be happy to provide you with a new kit at a discounted price to rerun the test. Please contact Customer Support.

What is the best age to take the test?

As Alzheimer’s disease pathology can begin decades before symptom onset and your genetics and genetic predispositions won’t change throughout your lifetime, the GenoRisk test is appropriate to take at any age

What is the difference between dementia and Alzheimer’s disease?

Dementia is an umbrella term used to describe a variety of symptoms that impact memory, activities of daily living, and ability to communicate. Alzheimer’s disease is the most common form of dementia, though not everyone with dementia has Alzheimer’s disease.

When can I expect my GenoRisk results?

Your results will be ready 24-72 hours after your sample arrives at our laboratory.

Will you perform GenoRisk testing on children or minors?

The GenoRisk test is not intended for anyone under the age of 18.